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Cryo-trapping the Six-Coordinate, Distorted-Octahedral Active Site of Manganese Superoxide Dismutase - Borgstahl Lab


Structural Analysis of Peroxide-Soaked MnSOD Crystals Reveals Side-On Binding of Peroxide to Active-Site Manganese - Borgstahl Lab


Hexagonal form crystal structure of RPA 14/32 dimer; quaternary structure (red helices) varies with crystal form - Borgstahl lab


Orthorombic form crystal structure of RPA 14/32 dimer; quaternary structure (red helices) varies with crystal form - Borgstahl lab

Structure of the orthorhombic form of human inosine triphosphate pyrophosphatase - Borgstahl and Pavlov labs

Incommensurate crystallography figure from Biomolecular Crystallography based on work with incommensurately modulated Profilin:Actin crystalsBorgstahl lab


In the Marky lab - From left to right Dr. Prislan using the DSC, Uto resting after a long day, Dr. Marky preparing a sample on the CD and the ITC in the background.

The UNMC structural biology and molecular biophysics collaborative group at the University of Nebraska Medical Center apply 3D structural techniques and other biophysical methods to the analysis of important biological macromolecules, to drive research and direct the synthesis of novel therapeutics.  Structural biology and molecular biophysics applies the principles and techniques of biology, chemistry, computer science, physics and mathematics, to elucidate the governing forces and structures of biological macromolecules, supra-molecular structures, organelles, and cells.  Atomic images of the arrangement of amino acid side chains in 3D give the atomic details needed to visualize the active sites of enzymes, see the DNA binding sites of transcription factors and view the protein-protein interactions of signaling molecules.  Function can be understood through determination of atomic structures followed by sensible application of biophysical methods to measure and interpret the molecular forces involved.  These tools uncover the architecture of the macromolecules of life and reveal what causes their action and, in the case of disease, dysfunction.  Understanding the structure, function and energetics of medically relevant macromolecules can help researchers better understand the causes of cancer and aid in the development of drugs based on the structure of targeted proteins.

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